Rumex crispus Leaf Extract Inhibits Lipopolysaccharide-Induced Inflammatory Response in BV-2 Microglia Cells

Background: Microglial cells are immune that operate within the central nervous system. Abnormally activated microglia cause neuroinflammation, which is linked with neurodegenerative disease. Previous research has revealed Rumex crispus root extract exerts anti-inflammatory effects. However, it not known whether leaf (RLE) effects on murine microglial cells, such as BV-2 cells. This study proposed to investigate impact of RLE inducing inflammation by LPS in Methods: was used induce and then cell survival, changes levels inflammation-related factors pro-inflammatory cytokines, NF-κB MAPKs signaling pathway activity were evaluated presence or absence RLE. Results: treatment resulted a reduction nitric oxide (NO) production triggered without causing cytotoxic In addition, both protein mRNA expression iNOS COX-2, upregulated LPS, significantly decreased Also, effectively reduced transcriptional further suppressed increased inflammatory cytokines stimulation. Additionally, response stimulated via interference MAPK pathways. Conclusions: Taken together, our results confirm effective suppression induced Consequently, we suggest holds promise preventive agent against diseases responses.